Genetics 2010

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Research from 3 December 2010

  • Russo, P., Cesario, A., Rutella, S., Veronesi, G., Spaggiari, L., Galetta, D., Margaritora, S., Granone, P., and Greenberg, D. S. Impact of genetic variability in nicotinic acetylcholine receptors on nicotine addiction and smoking cessation treatment. Curr.Med.Chem.  29-11-2010. Abstract or full text available at: http://www.ncbi.nlm.nih.gov/pubmed/21110812

Research from 26 November 2010

  • Mozaffarieh, M., Konieczka, K., Hauenstein, D., Schoetzau, A., and Flammer, J. Half a pack of cigarettes a day more than doubles DNA breaks in circulating leukocytes. Tobacco Induced Diseases. 8[1], 14. 17-11-2010. Abstract or full text available at: http://www.ncbi.nlm.nih.gov/pubmed/21083877

Research from 19 November 2010

  • Culverhouse, R. C., Saccone, N. L., Stitzel, J. A., Wang, J. C., Steinbach, J. H., Goate, A. M., Schwantes-An, T. H., Grucza, R. A., Stevens, V. L., and Bierut, L. J. Uncovering hidden variance: pair-wise SNP analysis accounts for additional variance in nicotine dependence. Hum.Genet.  16-11-2010. Abstract or full text available at: http://www.ncbi.nlm.nih.gov/pubmed/21079997
  • Sieminska, A. [Searching for genes influencing tobacco smoking susceptibility.]. Pneumonol.Alergol.Pol. 78[6], 432-438. 2010. Abstract or full text available at: http://www.ncbi.nlm.nih.gov/pubmed/21077035

Research from 29 October 2010

Research from 22 October 2010

  • Sticozzi, C., Pecorelli, A., Belmonte, G., and Valacchi, G. Cigarette smoke affects ABCAl expression via Liver X receptor nuclear translocation in human keratinocytes. Int.J.Mol.Sci. 11[9], 3375-3386. 2010.
    Abstract or full text available at: http://www.ncbi.nlm.nih.gov/pubmed/20957101
  • Ma, W., Xu, J., Wang, Q., Xin, Y., Zhang, L., Zheng, X., Sun, K., Wang, H., Hui, R., and Huang, X. Interaction of functional NPC1 gene Polymorphism with smoking on coronary heart disease. BMC.Med.Genet. 11[1], 149. 18-10-2010.
    Abstract or full text available at: http://www.ncbi.nlm.nih.gov/pubmed/20955564
  • Hodgson, M. E., Poole, C. L., Olshan, A. F., North, K. E., Zeng, D., and Millikan, R. C. Smoking and selected DNA repair gene polymorphisms in controls: Systematic review and meta-analysis. Cancer Epidemiology, Biomarkers & Prevention . 8-10-2010.
    Abstract or full text available at: http://www.ncbi.nlm.nih.gov/pubmed/20935063

Research from 8 October 2010

  • Edmiston, J. S., Archer, K. J., Scian, M. J., Joyce, A. R., Zedler, B. K., and Murrelle, E. L. Gene expression profiling of peripheral blood leukocytes identifies potential novel biomarkers of chronic obstructive pulmonary disease in current and former smokers. Biomarkers . 1-10-2010.
    Abstract or full text available at: http://www.ncbi.nlm.nih.gov/pubmed/20887155
  • Sabitha, K., Reddy, M. V., and Jamil, K. Smoking related risk involved in individuals carrying genetic variants of CYP1A1 gene in head and neck cancer. Cancer Epidemiol. 34[5], 587-592. 2010.
    Abstract or full text available at: http://www.ncbi.nlm.nih.gov/pubmed/20887941
  • Winterer, G., Mittelstrass, K., Giegling, I., Lamina, C., Fehr, C., Brenner, H., Breitling, L. P., Nitz, B., Raum, E., Muller, H., Gallinat, J., Gal, A., Heim, K., Prokisch, H., Meitinger, T., Hartmann, A. M., Moller, H. J., Gieger, C., Wichmann, H. E., Illig, T., Dahmen, N., and Rujescu, D. Risk gene variants for nicotine dependence in the CHRNA5-CHRNA3-CHRNB4 cluster are associated with cognitive performance. Am.J.Med.Genet.B Neuropsychiatr.Genet.  30-9-2010.
    Abstract or full text available at: http://www.ncbi.nlm.nih.gov/pubmed/20886544

Research from 30 September 2010

  • Salah, G. B., Kamoun, H., Rebai, A., Youssef, A. B., Ayadi, H., Belghith-Mahfoudh, N., Fourati, A., Ayadi, H., and Fakhfakh, F. Sister chromatid exchange (SCE) and high-frequency cells (HFC) in peripheral blood lymphocytes of healthy Tunisian smokers. Mutation Research . 22-9-2010.
    Abstract or full text available at: http://www.ncbi.nlm.nih.gov/pubmed/20869462

Research from 24 September 2010

  • Hoft, N. R., Stitzel, J. A., Hutchison, K. E., and Ehringer, M. A. CHRNB2 Promoter Region: Association with subjective effects to nicotine and gene expression differences. Genes Brain Behav.  20-9-2010.
    Abstract or full text available at: http://www.ncbi.nlm.nih.gov/pubmed/20854418

Research from 17 September 2010

  • Martinez, V. D., Buys, T. P., Adonis, M., Benitez, H., Gallegos, I., Lam, S., Lam, W. L., and Gil, L. Arsenic-related DNA copy-number alterations in lung squamous cell carcinomas. Br.J.Cancer . 14-9-2010.
    Abstract or full text available at: http://www.ncbi.nlm.nih.gov/pubmed/20842114
  • Johnson, E. O., Chen, L. S., Breslau, N., Hatsukami, D., Robbins, T., Saccone, N. L., Grucza, R. A., and Bierut, L. J. Peer smoking and the nicotinic receptor genes: an examination of genetic and environmental risks for nicotine dependence. Addiction . 15-9-2010.
    Abstract or full text available at: http://www.ncbi.nlm.nih.gov/pubmed/20840187
  • Tanaka, F., Yamamoto, K., Suzuki, S., Inoue, H., Tsurumaru, M., Kajiyama, Y., Kato, H., Igaki, H., Furuta, K., Fujita, H., Tanaka, T., Tanaka, Y., Kawashima, Y., Natsugoe, S., Setoyama, T., Tokudome, S., Mimori, K., Haraguchi, N., Ishii, H., and Mori, M. Strong interaction between the effects of alcohol consumption and smoking on oesophageal squamous cell carcinoma among individuals with ADH1B and/or ALDH2 risk alleles. Gut . 9-9-2010. Abstract or full text available at: http://www.ncbi.nlm.nih.gov/pubmed/20833657

Research from 10 September 2010

  •   Li, M. D., Yoon, D., Lee, J. Y., Han, B. G., Niu, T., Payne, T. J., Ma, J. Z., and Park, T. Associations of variants in CHRNA5/A3/B4 gene cluster with smoking behaviors in a Korean population. PLoS.One. 5[8]. 2010.
    Abstract or full text available at: http://www.ncbi.nlm.nih.gov/pubmed/20808433
  • Sato, N., Kageyama, S., Chen, R., Suzuki, M., Mori, H., Tanioka, F., Yamada, H., Kamo, T., Tao, H., Shinmura, K., Nozawa, A., and Sugimura, H. Association between neuropeptide Y receptor 2 polymorphism and the smoking behavior of elderly Japanese. Journal of Human Genetics . 2-9-2010.
    Abstract or full text available at: http://www.ncbi.nlm.nih.gov/pubmed/20811389
  • Uhl, G. R., Drgon, T., Johnson, C., Ramoni, M. F., Behm, F. M., and Rose, J. E. Genome wide association for smoking cessation success in a trial of precessation nicotine replacement. Molecular Medicine . 24-8-2010.
    Abstract or full text available at: http://www.ncbi.nlm.nih.gov/pubmed/20811658
  • Zappacosta, B., Martorana, G. E., Papini, S., Gervasoni, J., Iavarone, F., Fasanella, S., Giardina, B., De Sole, P., and Persichilli, S. Morpho-functional modifications of human neutrophils induced by aqueous cigarette smoke extract: comparison with chemiluminescence activity. Luminescence.  31-8-2010.
    Abstract or full text available at: http://www.ncbi.nlm.nih.gov/pubmed/20812198
     

Research from 27 August 2010

  • El Zein, R. A., Monroy, C. M., Cortes, A., Spitz, M. R., Greisinger, A., and Etzel, C. J. Rapid method for determination of DNA repair capacity in human peripheral blood lymphocytes amongst smokers. BMC.Cancer 10[1], 439. 18-8-2010.  Abstract or full text available at: http://www.ncbi.nlm.nih.gov/pubmed/20718982
  • Erlich, P. M., Hoffman, S. N., Rukstalis, M., Han, J. J., Chu, X., Linda Kao, W. H., Gerhard, G. S., Stewart, W. F., and Boscarino, J. A. Nicotinic acetylcholine receptor genes on chromosome 15q25.1 are associated with nicotine and opioid dependence severity. Hum.Genet.  20-8-2010.  Abstract or full text available at: http://www.ncbi.nlm.nih.gov/pubmed/20725741

Research from 20 August 2010

  • Babizhayev, M. A. and Yegorov, Y. E. Smoking and health: association between telomere length and factors impacting on human disease, quality of life and life span in a large population-based cohort under the effect of smoking duration. Fundam.Clin.Pharmacol.  31-7-2010.
    Abstract or full text available at: http://www.ncbi.nlm.nih.gov/pubmed/20698892
  • De Ruyck, K., Nackaerts, K., Beels, L., Werbrouck, J., De Volder, A., Meysman, M., Salhi, B., Van Meerbeeck, J., and Thierens, H. Genetic variation in three candidate genes and nicotine dependence, withdrawal and smoking cessation in hospitalized patients. Pharmacogenomics. 11[8], 1053-1063. 2010.
    Abstract or full text available at: http://www.ncbi.nlm.nih.gov/pubmed/20712524
  • Saccone, N. L., et al. Multiple independent loci at chromosome 15q25.1 affect smoking quantity: a meta-analysis and comparison with lung cancer and COPD. PLoS.Genet. 6[8]. 2010.
    Abstract or full text available at: http://www.ncbi.nlm.nih.gov/pubmed/20700436

Research from 13 August 2010

  • Nakanishi, H., Yamashiro, K., Yamada, R., Gotoh, N., Hayashi, H., Nakata, I., Saito, M., Iida, T., Oishi, A., Kurimoto, Y., Matsuo, K., Tajima, K., Matsuda, F., and Yoshimura, N. Joint Effect of Cigarette Smoking, CFH and LOC387715/HTRA1 Polymorphisms on Polypoidal Choroidal Vasculopathy. Invest Ophthalmol.Vis.Sci.  4-8-2010.
    Abstract or full text available at: http://www.ncbi.nlm.nih.gov/pubmed/20688737

Research from 6 August 2010

  • Gabriel, U., Steidler, A., Trojan, L., Michel, M. S., Seifarth, W., and Fabarius, A. Smoking increases transcription of human endogenous retroviruses in a newly established in vitro cell model and in normal urothelium. AIDS Res.Hum.Retroviruses . 28-7-2010.
    Abstract or full text available at: http://www.ncbi.nlm.nih.gov/pubmed/20666582


Research from 30 July 2010

  • Charlesworth, J. C., Curran, J. E., Johnson, M. P., Goring, H. H., Dyer, T. D., Diego, V. P., Kent, J. W., Jr., Mahaney, M. C., Almasy, L., Maccluer, J. W., Moses, E. K., and Blangero, J. Transcriptomic epidemiology of smoking: the effect of smoking on gene expression in lymphocytes. BMC.Med.Genomics 3[1], 29. 15-7-2010.
    Abstract or full text available at: http://www.ncbi.nlm.nih.gov/pubmed/20633249
  • Zhang, H., Kranzler, H. R., Poling, J., and Gelernter, J. Variation in the nicotinic acetylcholine receptor gene cluster CHRNA5-CHRNA3-CHRNB4 and its interaction with recent tobacco use influence cognitive flexibility. Neuropsychopharmacology . 14-7-2010.
    Abstract or full text available at: http://www.ncbi.nlm.nih.gov/pubmed/20631687


Research from 16 July 2010

  • Grucza, R. A., Johnson, E. O., Krueger, R. F., Breslau, N., Saccone, N. L., Chen, L. S., Derringer, J., Agrawal, A., Lynskey, M., and Bierut, L. J. Incorporating age at onset of smoking into genetic models for nicotine dependence: evidence for interaction with multiple genes. Addict.Biol. 15[3], 346-357. 2010.   Abstract or full text available at: http://www.ncbi.nlm.nih.gov/pubmed/20624154
  • Hallberg, J., Iliadou, A., Anderson, M., Gerhardsson, de, V, Nihlen, U., Dahlback, M., Pedersen, N. L., Higenbottam, T., and Svartengren, M. Genetic and environmental influence on lung function impairment in Swedish twins. Respir.Res. 11[1], 92. 6-7-2010. Abstract or full text available at: http://www.ncbi.nlm.nih.gov/pubmed/20604964

Research from 2 July 2010

  • Kupfer, D. M., White, V. L., Jenkins, M. C., and Burian, D. Examining smoking-induced differential gene expression changes in buccal mucosa. BMC.Med.Genomics 3[1], 24. 24-6-2010.
    Abstract or full text available at: http://www.ncbi.nlm.nih.gov/pubmed/20576139
  • Saccone, N. L., Schwantes-An, T. H., Wang, J. C., Grucza, R. A., Breslau, N., Hatsukami, D., Johnson, E. O., Rice, J. P., Goate, A. M., and Bierut, L. J. Multiple cholinergic nicotinic receptor genes affect nicotine dependence risk in African and European Americans. Genes Brain Behav.  22-6-2010.
    Abstract or full text available at: http://www.ncbi.nlm.nih.gov/pubmed/20584212


Research from 25 June 2010

  • Song, Z., von Figura, G., Liu, Y., Kraus, J. M., Torrice, C., Dillon, P., Rudolph-Watabe, M., Ju, Z., Kestler, H. A., Sanoff, H., and Lenhard, Rudolph K. Lifestyle impacts on the aging associated expression of biomarkers of DNA damage and telomere dysfunction in human blood. Aging Cell . 17-6-2010.
    Abstract or full text available at: http://www.ncbi.nlm.nih.gov/pubmed/20560902

Research from 28 May 2010

  • Berg, J. Z., von Weymarn, L. B., Thompson, E. A., Wickham, K. M., Weisensel, N. A., Hatsukami, D. K., and Murphy, S. E. UGT2B10 Genotype Influences Nicotine Glucuronidation, Oxidation, and Consumption. Cancer Epidemiol.Biomarkers Prev.  25-5-2010.
    Abstract or full text available at: http://www.ncbi.nlm.nih.gov/pubmed/20501767

Research from 21 May 2010

  • Unverdorben, M., Holt, K., and Winkelmann, B. R. Smoking and atherosclerotic cardiovascular disease: Part III: Functional biomarkers influenced by smoking. Biomark.Med. 3[6], 807-823. 2009.   Abstract or full text available at: http://www.ncbi.nlm.nih.gov/pubmed/20477716
  • Sticchi, E., Sofi, F., Romagnuolo, I., Pratesi, G., Pulli, R., Pratesi, C., Abbate, R., and Fatini, C. eNOS and ACE genes influence peripheral arterial disease predisposition in smokers. J.Vasc.Surg.  15-5-2010.    Abstract or full text available at: http://www.ncbi.nlm.nih.gov/pubmed/20478683
  • Flatscher-Bader, T., Harrison, E., Matsumoto, I., and Wilce, P. A. Genes Associated With Alcohol Abuse and Tobacco Smoking in the Human Nucleus Accumbens and Ventral Tegmental Area. Alcohol Clin.Exp.Res.  4-5-2010.   Abstract or full text available at: http://www.ncbi.nlm.nih.gov/pubmed/20477762
  • New research shows genetic chaos caused by smoking. Results provide a "cancer map" that catalogues mutations; findings could revolutionize cancer treatment. Duke.Med.Health News 16[3], 5-6. 2010.   Abstract or full text available at: http://www.ncbi.nlm.nih.gov/pubmed/20461882

Research from 7 May 2010

  • Rana, G. S., York, T. P., Edmiston, J. S., Zedler, B. K., Pounds, J. G., Adkins, J. N., Smith, R. D., Liu, Z., Li, G., Webb, B. T., Murrelle, E. L., and Flora, J. W. Proteomic biomarkers in plasma that differentiate rapid and slow decline in lung function in adult cigarette smokers with chronic obstructive pulmonary disease (COPD). Anal.Bioanal.Chem.  5-5-2010.
    Abstract or full text available at: http://www.ncbi.nlm.nih.gov/pubmed/20442989
  • Chai, L., Song, Y. Q., Zee, K. Y., and Leung, W. K. SNPs of Fc-gamma Receptor Genes and Chronic Periodontitis. J.Dent.Res.  3-5-2010.
    Abstract or full text available at: http://www.ncbi.nlm.nih.gov/pubmed/20439936
  • Canova, C., Richiardi, L., Merletti, F., Pentenero, M., Gervasio, C., Tanturri, G., Garzino-Demo, P., Pecorari, G., Talamini, R., Barzan, L., Sulfaro, S., Franchini, G., Muzzolini, C., Bordin, S., Pugliese, G. N., Macri, E., and Simonato, L. Alcohol, tobacco and genetic susceptibility in relation to cancers of the upper aerodigestive tract in northern Italy. Tumori 96[1], 1-10. 2010.
    Abstract or full text available at: http://www.ncbi.nlm.nih.gov/pubmed/20437850
  • Taghavi, N., Biramijamal, F., Abbaszadegan, M. R., Khademi, H., Sotoudeh, M., and Khoshbakht, S. P21(waf1/cip1)Gene Polymorphisms and Possible Interaction with Cigarette Smoking in Esophageal Squamous Cell Carcinoma in Northeastern Iran: A Preliminary Study. Arch.Iran Med. 13[3], 235-242. 2010.
    Abstract or full text available at: http://www.ncbi.nlm.nih.gov/pubmed/20433229
  • Amos, C. I., Spitz, M. R., and Cinciripini, P. Chipping away at the genetics of smoking behavior. Nat.Genet. 42[5], 366-368. 2010.
    Abstract or full text available at: http://www.ncbi.nlm.nih.gov/pubmed/20428092 

Research from 30 April 2010

  • Boardman, J. D., Blalock, C. L., and Pampel, F. C. Trends in the genetic influences on smoking. J.Health Soc.Behav. 51[1], 108-123. 2010.
    Abstract or full text available at: http://www.ncbi.nlm.nih.gov/pubmed/20420298
  • Furberg, H. et al Genome-wide meta-analyses identify multiple loci associated with smoking behavior. Nat.Genet.  25-4-2010. Abstract or full text available at: http://www.ncbi.nlm.nih.gov/pubmed/20418890
  • Furberg, H., Ostroff, J., Lerman, C., and Sullivan, P. F. The public health utility of genome-wide association study results for smoking behavior. Genome Med. 2[4], 26. 27-4-2010. Abstract or full text available at: http://www.ncbi.nlm.nih.gov/pubmed/20423533
  • Koth, L. L., Cambier, C. J., Ellwanger, A., Solon, M., Hou, L., Lanier, L. L., Abram, C. L., Hamerman, J. A., and Woodruff, P. G. DAP12 Is Required for Macrophage Recruitment to the Lung in Response to Cigarette Smoke and Chemotaxis toward CCL2. J.Immunol.  26-4-2010. Abstract or full text available at: http://www.ncbi.nlm.nih.gov/pubmed/20421649
  • Liu, J. Z., et al. Meta-analysis and imputation refines the association of 15q25 with smoking quantity. Nat.Genet.  25-4-2010.
    Abstract or full text available at: http://www.ncbi.nlm.nih.gov/pubmed/20418889
  • Thorgeirsson, T. E. et al. Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior. Nat.Genet.  25-4-2010. Abstract or full text available at: http://www.ncbi.nlm.nih.gov/pubmed/20418888
  • Winkelmann, B. R., von Holt, K., and Unverdorben, M. Smoking and atherosclerotic cardiovascular disease: Part IV: Genetic markers associated with smoking. Biomark.Med. 4[2], 321-333. 2010. Abstract or full text available at: http://www.ncbi.nlm.nih.gov/pubmed/20406073
  • Xie, Y. H., Wang, S. W., Zhang, Y., Edvinsson, L., and Xu, C. B. Up-Regulation of G-Protein-Coupled Receptors for Endothelin and Thromboxane by Lipid-Soluble Smoke Particles in Renal Artery of Rat. Basic Clin.Pharmacol.Toxicol.  14-4-2010.
    Abstract or full text available at: http://www.ncbi.nlm.nih.gov/pubmed/20406207

Research from 23 April 2010

  • Jorgensen, E. D., Zhao, H., Traganos, F., Albino, A. P., and Darzynkiewicz, Z. DNA damage response induced by exposure of human lung adenocarcinoma cells to smoke from tobacco- and nicotine-free cigarettes. Cell Cycle 9[11]. 22-6-2010. Abstract or full text available at: http://www.ncbi.nlm.nih.gov/pubmed/20404482

Research from 26 February 2010

  • Speletas, M., Merentiti, V., Kostikas, K., Liadaki, K., Minas, M., Gourgoulianis, K., and Germenis, A. E. Association of TLR4-T399I Polymorphism with Chronic Obstructive Pulmonary Disease in Smokers. Clin.Dev.Immunol. 2009, 260286. 2009.  Abstract or full text available at: http://www.ncbi.nlm.nih.gov/pubmed/20169003
  • Guo, G., Cai, T., Guo, R., Wang, H., and Harris, K. M. The dopamine transporter gene, a spectrum of most common risky behaviors, and the legal status of the behaviors. PLoS.One. 5[2], e9352. 2010.  Abstract or full text available at: http://www.ncbi.nlm.nih.gov/pubmed/20179766
  • Spira, A. Upper Airway Gene Expression in Smokers: The Mouth as a "Window to the Soul" of Lung Carcinogenesis? Cancer Prev.Res.(Phila Pa) . 23-2-2010.   Abstract or full text available at: http://www.ncbi.nlm.nih.gov/pubmed/20179303
  • Fong, P. Y., Fesinmeyer, M. D., White, E., Farin, F. M., Srinouanprachanh, S., Afsharinejad, Z., Mandelson, M. T., Brentnall, T. A., Barnett, M. J., Goodman, G. E., and Austin, M. A. Association of Diabetes Susceptibility Gene Calpain-10 with Pancreatic Cancer Among Smokers. J.Gastrointest.Cancer . 23-2-2010.   Abstract or full text available at: http://www.ncbi.nlm.nih.gov/pubmed/20178008

Research from 19 February 2010

  • Ray, R., Mitra, N., Baldwin, D., Guo, M., Patterson, F., Heitjan, D. F., Jepson, C., Wileyto, E. P., Wei, J., Payne, T., Ma, J. Z., Li, M. D., and Lerman, C. Convergent evidence that choline acetyltransferase gene variation is associated with prospective smoking cessation and nicotine dependence. Neuropsychopharmacology . 10-2-2010.
    Abstract or full text available at: http://www.ncbi.nlm.nih.gov/pubmed/20147892
     

Research from 5 February 2010

  • Rondelli, C. M., El Zein, R. A., Wickliffe, J. K., Etzel, C. J., and Abdel-Rahman, S. Z. A comprehensive haplotype analysis of the XPC genomic sequence reveals a cluster of genetic variants associated with sensitivity to tobacco-smoke mutagens. Toxicol.Sci.  27-1-2010. Abstract or full text available at: http://www.ncbi.nlm.nih.gov/pubmed/20106949

Research from 12 February 2010

  • David, S. P., Mezuk, B., Zandi, P. P., Strong, D., Anthony, J. C., Niaura, R., Uhl, G. R., and Eaton, W. W. Sex differences in TTC12/ANKK1 haplotype associations with daily tobacco smoking in Black and White Americans. Nicotine.Tob.Res.  4-2-2010.   Abstract or full text available at: http://www.ncbi.nlm.nih.gov/pubmed/20133381
  • Mwenifumbo, J. C., Zhou, Q., Benowitz, N. L., Sellers, E. M., and Tyndale, R. F. New CYP2A6 gene deletion and conversion variants in a population of Black African descent. Pharmacogenomics. 11[2], 189-198. 2010.   Abstract or full text available at: http://www.ncbi.nlm.nih.gov/pubmed/20136358

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