Taking action on smoking and health
New research 22 July 2014Ramirez, N., et al. Exposure to nitrosamines in thirdhand tobacco smoke increases cancer risk in non-smokers. Environment International. October 2014The results of this research highlight the potentially severe long-term consequences of thirdhand smoke exposure, particularly to children, and give strong evidence of its potential health risk.Research 06 February 2014Martins-Green M, Adhami N, Frankos M, Valdez M, Goodwin B, et al. (2014) Cigarette Smoke Toxins Deposited on Surfaces: Implications for HumanHealth. PLoS ONE 9(1): e86391. doi:10.1371/journal.pone.0086391 Third-hand smoke (THS) -exposed mice show alterations in multiple organ systems and excrete levels of NNAL (a tobacco-specific carcinogen biomarker) similar to those found in children exposed to SHS (and consequently to THS). In liver, THS leads to increased lipid levels and non-alcoholic fatty liver disease, a precursor to cirrhosis and cancer and a potential contributor to cardiovascular disease. In lung, THS stimulates excess collagen production and high levels of inflammatory cytokines, suggesting propensity for fibrosis with implications for inflammation-induced diseases such as chronic obstructive pulmonary disease and asthma. In wounded skin, healing in THS-exposed mice has many characteristics of the poor healing of surgical incisions observed in human smokers. Lastly, behavioral tests show that THS-exposed mice become hyperactive. The latter data, combined with emerging associated behavioral problems in children exposed to SHS/THS, suggest that, with prolonged exposure, they may be at significant risk for developing more severe neurological disorders. These results provide a basis for studies on the toxic effects of THS in humans and inform potential regulatory policies to prevent involuntary exposure to THS.Research 24 June 2013Hang, B. et al. Thirdhand smoke causes DNA damage in human cell. Mutagenesis. [Online] 28 (4): 381-391, 2013. Available from: http://mutage.oxfordjournals.org/content/28/4/381
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